cc chemokines การใช้

• This chemokine resides in a large cluster of CC chemokines on human chromosome 17.
• Its gene is located on human chromosome 17 within a large cluster of other CC chemokines.
• Its gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22.
• In the human genome, CCL2 and many other CC chemokines are located on chromosome 17 ( 17q11.2-q21.1 ).
• Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines.
• This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most closely related to CCL2 ( previously called MCP1 ).
• Chemokine receptors are G protein-coupled receptors containing 7 CCR that bind CC chemokines, CX3CR1 that binds the sole CX3C chemokine ( CX3CL1 ), and XCR1 that binds the two XC chemokines ( XCL1 and XCL2 ).
• Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.
• The family members stimulate another blood cell of the innate immunity system, the human monocyte, acting synergistically with the pro-inflammatory CC chemokines, monocyte chemotactic protein-1 and monocyte chemotactic protein-3, to stimulate monocyte function . 5-Oxo-ETE also stimulates two other cell types that share responsibility with the PMN for regulating inflammation, the human lymphocyte and dendritic cell.